Advanced Neuroprotective Blend
Cognitive
Triple neuroprotective blend for sleep, neuroregeneration, and calm focus.
About
Pinealon/PE-22-28/Selank is a triple-peptide neuroprotective blend, each component covering a different pillar of brain health. Pinealon is a three-amino-acid bioregulator from the Khavinson school, studied for protecting neurons under oxidative stress in cell and rodent models. Despite the name, it was isolated from a brain-cortex preparation, and no study has measured its effect on the pineal gland, melatonin or sleep. PE-22-28 is a neurotrophic peptide that raises BDNF, the growth factor your brain uses to build and strengthen neural connections for memory and learning. Selank modulates GABA and serotonin to reduce anxiety without sedation.
Together they feed a calmer, more adaptive nervous system: sharper cognition and recall, a steadier emotional baseline so stress stops hijacking your focus, and support for neural repair. Three mechanisms, one daily injection: calm, repair, and cognition addressed at once.
PeRx ships Pinealon/PE-22-28/Selank fully reconstituted from a state-licensed 503A pharmacy. No mixing. Insulin syringes and a step-by-step guide arrive in the box. It is a subcutaneous injection, often run in cycles, on a provider-determined schedule.
Pinealon is studied for protecting neurons under stress, not for the sleep its name suggests.
Selank modulates GABA and serotonin pathways for steady mood and calm, no sedation and no morning grogginess on the back end.
PE-22-28 raises BDNF production, the growth factor your brain uses to build fresh neural connections for memory and clearer thinking.
All three peptides feed a calmer, more adaptive nervous system, so stress stops hijacking your focus and emotional bandwidth.
Long-term neuroprotection in a single daily injection. Three peptides, three mechanisms, one vial for sleep, repair, and cognition.
Why people explore Pinealon/PE-22-28/Selank
Pinealon is a Khavinson tripeptide studied for protecting neurons under oxidative stress in cell and rodent models. Despite the name, no study has measured an effect on the pineal gland, melatonin or sleep, so any early change in sleep is more plausibly the calming effect of Selank.
PE-22-28 raises BDNF, the growth factor your brain uses to build, maintain, and strengthen neural connections, which downstream means sharper focus, faster learning, and better memory consolidation.
Selank shifted expression across genes tied to mood and stress within an hour of dosing in clinical research.
Selank modulates GABA and serotonin to take the edge off background anxiety, steadier mood, no morning grogginess. All three peptides together produce a calmer, more resilient nervous system.
What it helps with
Ideal for
Those seeking comprehensive brain health support · Individuals with sleep and cognitive concerns · Those wanting neuroprotection alongside focus · Adults interested in advanced nootropic protocols
The science
Pinealon has been studied for neuroprotection in cell culture and rodents; despite its name, no study has measured its effect on melatonin or sleep. PE-22-28 promotes neurogenesis and synaptic plasticity in animal models. Selank modulates GABA and serotonin for anxiolytic effects. Together they address stress, repair, and cognitive performance.
Pinealon/PE-22-28/Selank is given as a subcutaneous injection, often in cycles, on a provider-determined schedule.
Pinealon is studied for neuroprotection in cell and rodent models; no study has measured an effect on melatonin or sleep. PE-22-28 promotes neurogenesis and synaptic plasticity in animal models. Selank modulates GABA and serotonin for anxiolytic effects. Together they address stress, neural repair, and cognitive performance.
Over the following weeks most people notice deeper sleep first, sometimes vivid dreams as architecture normalizes (weeks 1–2), then waking up genuinely rested with the mental fog lifting and focus sharpening (weeks 2–4), then consistent high-quality sleep, better memory, and effortless emotional regulation (weeks 4–12). Many run periodic cycles.
What the research shows
3 peptides
Neuroprotection (Pinealon) + cognition (PE-22-28) + calm (Selank) in one vial
↑ BDNF
The learning/memory growth factor PE-22-28 raises
Cell + rodent
Where the Pinealon neuroprotection evidence sits
No sedation
Selank reduces anxiety without the grogginess of sedatives
Our medication is delivered from a state-licensed pharmacy in our network, right to your door when you need it.
Our pharmacies perform third-party testing through FDA and DEA registered labs to run quality control checks for every compounded lot. They test four key characteristics associated with quality and safety.
Performed on every batch to confirm the active ingredient is present at the labeled concentration. Your vial contains exactly what it should.
Tests for the presence of bacteria, fungi, and other microorganisms. Every batch is tested and must meet the requirements of USP 797.1.
Screens for bacterial endotoxins that can cause fever or adverse reactions. Every batch is tested and must not exceed the threshold limits defined in USP 85.
Assesses the acid/base balance to ensure minimal irritation upon injection and confirm the solution is within the correct range for subcutaneous administration.
What to expect
Week 1–2
What you may notice: Anxiety may start to soften, which is the effect with the most human data behind it (Selank). Some people report vivid dreams in the first few days.
What’s happening: Selank is beginning to modulate GABA and serotonin. PE-22-28 is initiating BDNF upregulation, based on animal work. Whatever Pinealon does at the cellular level has not been measured in people.
Week 2–4
What you may notice: Waking up feeling genuinely rested. Mental fog lifting. Focus sharpening during demanding tasks. Stress responses feel more manageable.
What’s happening: BDNF levels are rising, supporting new neural connections. Anxiolytic effects from Selank are well established. Any change in sleep is a reported experience rather than a measured effect.
Week 4–8
What you may notice: Consistent, high-quality sleep. Noticeably better memory and cognitive performance. Emotional regulation feels natural rather than effortful.
What’s happening: All three peptides are delivering compounding effects. Neuroplasticity is enhanced, the brain is building new pathways while maintaining existing ones more effectively.
Week 8–12+
What you may notice: Stable sleep, sharp cognition, and calm focus are the new baseline. Many people continue on a maintenance protocol or cycle periodically.
What’s happening: The neuroprotective foundation is established. Sleep, cognitive function, and emotional regulation are operating from a higher baseline. Many patients adopt a cycling protocol for long-term brain health.
Comparison
Selank's calm focus plus two more pillars. Here's the difference.
| Pinealon/PE-22-28/Selank | Semax/Selank | |
|---|---|---|
| Best for | Complete brain health, sleep + cognition + mood | Anxiety relief and calm focus |
| How it works | Neuroprotection (Pinealon) + BDNF boost (PE-22-28) + GABA modulation (Selank) | BDNF boost (Semax) + GABA/serotonin modulation (Selank) |
| Scope | Three pillars: sleep, neural growth, emotional regulation | Cognition and anxiety |
| Best if you have | Poor sleep, brain fog, and background anxiety | Anxiety or stress without major sleep issues |
| Can combine? | Yes, pairs well with DSIP, Epitalon | Yes, pairs well with Thymosin Alpha-1, Epitalon |
What’s included
From the moment you finish your assessment to your first dose, every step is handled by licensed providers and U.S. pharmacies.
New to self-injection? See the step-by-step guideFAQ
Patient reviews
Using this combo has made focus hold longer during long work stretches and recovery from mental overload feel quicker. Sleep quality improved a bit too, and the usual post-stress crash is muted.
Memory recall feels sharper and the overall mental noise is dialed down. One of the more balanced nootropic stacks I’ve run.
I love this stack, my emotional resilience is so much better. Things that used to spiral stay manageable, and motivation comes back easier after tough days.
This is not medical advice. Every patient's experience differs and not everyone qualifies for peptide therapy. All reviews are from verified PeRx patients and are published as submitted. Peptide therapy requires a valid prescription from a licensed provider.
Your safety, first
All prescriptions are issued by a licensed US provider after reviewing your intake.
Side effects, contraindications, and what to discuss with your provider before starting.
Read safety informationSupporting research
A selection of peer-reviewed work on Pinealon/PE-22-28/Selank. Browse the full literature on PubMed and Google Scholar for ongoing research.
Pinealon neuroprotection in cell culture
Khavinson V, Ribakova Y, Kalinin K, et al. Rejuvenation Res. 2011;14(5):535-41.BDNF and cognitive function (review)
Bekinschtein P et al. Nat Rev Neurosci. 2013.Selank: anxiolytic and nootropic properties
Ershov FI et al. Regul Pept. 2014.The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The FDA does not review or approve compounded medications for safety or effectiveness. Off-label use must be prescribed and supervised by a licensed provider.
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Last updated April 2026
Medical disclaimer
The information provided on this page is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. Peptide therapy requires a valid prescription from a licensed healthcare provider. Individual results may vary. No specific outcomes are guaranteed.
The peptides on this site are not FDA-approved. They are compounded by licensed pharmacies under provider supervision. Certain peptides are prohibited by WADA and major sports organizations. Statements on this page have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
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