Pinealon/PE-22-28/Selank Injection
Advanced Neuroprotective Blend
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Get StartedPinealon/PE-22-28/Selank is a triple-peptide neuroprotective blend. Pinealon regulates melatonin synthesis and circadian rhythm. PE-22-28 boosts brain-derived neurotrophic factor (BDNF) for cognitive function and neuroprotection. Selank modulates GABA and serotonin to reduce anxiety without sedation. Together they address three pillars of brain health in one formulation.
This combination may support improved sleep quality and circadian rhythm restoration, enhanced cognitive clarity and memory, reduced anxiety without sedation or cognitive impairment, increased neuroplasticity, and overall neuroprotection. All benefits are based on published research and individual results may vary.
Pinealon/PE-22-28/Selank is administered as a simple subcutaneous injection. Typical dosing includes one injection per day on a provider-determined schedule. PeRx ships it fully reconstituted and ready to use. Insulin syringes and a step-by-step guide are included.
The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
*The FDA does not review or approve any compounded medications for safety or effectiveness. Off-label use must be prescribed and supervised by a licensed provider.
Sleep better. Think clearer. Stress less.
Poor sleep, brain fog, and low-grade anxiety rarely show up alone. They feed each other. Bad sleep makes you foggy. Fog makes you anxious. Anxiety ruins your sleep. Most treatments target one piece and leave the rest spinning.
This blend was designed to break that cycle. Pinealon restores your natural sleep architecture at the circadian level. PE-22-28 grows new neural connections through BDNF. Selank calms the anxiety response through GABA modulation without dulling your thinking. Three peptides, three mechanisms, one vial.
Why do people explore Pinealon/PE-22-28/Selank therapy?
May restore natural sleep architecture and circadian rhythm. Pinealon acts on the pineal gland to regulate melatonin synthesis at the genetic level.
May reduce anxiety and stabilize mood without sedation. Selank modulates GABA and serotonin pathways, keeping you calm and focused.
May enhance cognitive clarity and memory through PE-22-28, which boosts BDNF production for new neural connections.
May improve stress resilience and emotional regulation. All three peptides contribute to a calmer, more adaptive nervous system.
May support long-term neuroprotection. This blend addresses sleep, repair, and cognitive performance in a single daily injection.
Ready to get started?
Provider-prescribed Pinealon/PE-22-28/Selank, delivered to your door.
Get Started
Three peptides. Three mechanisms. How Pinealon, PE-22-28, and Selank address sleep, cognition, and anxiety in a single blend. Read the guide →
What the research shows about Pinealon/PE-22-28/Selank
Lab tested medications
for quality & potency
Our medication is compounded at FDA-registered, state-licensed 503A pharmacies and delivered right to your door when you need it.
Lab tested for quality & potency
Our pharmacies perform third-party testing through FDA and DEA registered labs to run quality control checks for every compounded lot. They test four key characteristics associated with quality and safety.
Potency Test
PASSEDPerformed on every batch to confirm the active ingredient is present at the labeled concentration. Your vial contains exactly what it should.
Sterility Test
PASSEDTests for the presence of bacteria, fungi, and other microorganisms. Every batch is tested and must meet the requirements of USP 797.1.
Endotoxin Test
PASSEDScreens for bacterial endotoxins that can cause fever or adverse reactions. Every batch is tested and must not exceed the threshold limits defined in USP 85.
pH Test
PASSEDAssesses the acid/base balance to ensure minimal irritation upon injection and confirm the solution is within the correct range for subcutaneous administration.
Quality you can trust
Get started in 3 simple steps
No appointments. No waiting rooms. Everything happens online.
Complete your health screening online
Step
1
Answer a quick clinical questionnaire 100% online. A licensed provider reviews your profile to determine if a personalized treatment plan is right for you.
Get your medication delivered to your door
Step
2
Once approved, your prescription ships directly to you via FedEx Overnight in cold-chain packaging. Fully reconstituted and ready to use from day one.
Ongoing care and provider support
Step
3
Your prescribing provider is available anytime for questions. Plus, regular check-ins help track your progress and adjust your protocol as needed.
Pinealon/PE-22-28/Selank vs. Semax/Selank
Both support cognitive health. Here's how the triple blend goes further.
Pinealon/PE-22-28/Selank
Sleep + cognition + calm
| Pinealon/PE-22-28/Selank | Semax/Selank | |
|---|---|---|
| Best For | Complete brain health (sleep + cognition + mood) | Anxiety relief and calm focus |
| How It Works | Circadian repair + BDNF boost + GABA modulation | GABA and serotonin modulation |
| Scope | Three pillars: sleep, neural growth, emotional regulation | Primarily anxiolytic and cognitive |
| Ideal If You Have | Poor sleep, brain fog, and background anxiety | Anxiety or stress without major sleep issues |
| Can Combine? | Yes — pairs well with DSIP, Epitalon | Yes — pairs well with Thymosin Alpha-1, Epitalon |
Looking for anxiety and focus without sleep support?
Semax/Selank is a dual-peptide blend focused on anxiety relief and cognitive performance. If sleep is not your primary concern, it may be the right starting point.
View Semax/Selank
Semax/Selank
Anxiety relief + focus
What to Expect: Your Pinealon/PE-22-28/Selank Timeline
Every body is different, but here's the typical progression.
What you may notice:
Sleep may feel deeper and more restorative. You may notice vivid dreams in the first few days as sleep architecture begins normalizing. Anxiety may start to soften.
What's happening:
Pinealon is recalibrating melatonin production and circadian gene expression. Selank is beginning to modulate GABA and serotonin. PE-22-28 is initiating BDNF upregulation.
What you may notice:
Waking up feeling genuinely rested. Mental fog lifting. Focus sharpening during demanding tasks. Stress responses feel more manageable.
What's happening:
Sleep architecture is stabilizing into healthy patterns. BDNF levels are rising, supporting new neural connections. Anxiolytic effects from Selank are well established.
What you may notice:
Consistent, high-quality sleep. Noticeably better memory and cognitive performance. Emotional regulation feels natural rather than effortful.
What's happening:
All three peptides are delivering compounding effects. Neuroplasticity is enhanced. The brain is building new pathways while maintaining existing ones more effectively.
What you may notice:
Stable sleep, sharp cognition, and calm focus are the new baseline. Many people continue on a maintenance protocol or cycle periodically.
What's happening:
The neuroprotective foundation is established. Sleep, cognitive function, and emotional regulation are operating from a higher baseline. Many patients adopt a cycling protocol for long-term brain health.
More from our patients
Real experiences. Individual results may vary.
Best sleep I have had in years
“I have tried melatonin, magnesium, every sleep supplement on the market. Nothing fixed my broken sleep cycle. Two weeks on this blend and I am sleeping through the night and waking up sharp. The difference in my focus during the day is obvious.”
Andrew H.
Pinealon/PE-22-28/Selank
Anxiety relief without the fog
“I was on a low-dose benzo for years and hated how it dulled my thinking. My provider switched me to this blend and the anxiety relief is comparable but my mind is clearer than it has been in a long time. No sedation, no dependence.”
Karen L.
Pinealon/PE-22-28/Selank
The brain fog finally lifted
“Post-COVID brain fog had me struggling at work for over a year. Started this protocol and by week three I could actually hold a complex thought again. By week six my productivity was back to where it was before I got sick.”
Marcus T.
Pinealon/PE-22-28/Selank
Professional process, real results
“PeRx made the whole experience feel like a legitimate medical process. Provider reviewed everything, medication arrived next day. The triple blend is exactly what I needed for my sleep and stress.”
Jennifer W.
Pinealon/PE-22-28/Selank
Three problems, one solution
“Bad sleep, constant low-level anxiety, and brain fog that would not quit. My provider suggested this blend because it addresses all three. By month two I felt like a completely different person. Sleeping well, thinking clearly, and calm.”
Steven R.
Pinealon/PE-22-28/Selank
Individual results may vary. Testimonials reflect personal experiences and do not guarantee outcomes.
Learn more about
Pinealon/PE-22-28/Selank Injection
Pinealon/PE-22-28/Selank is a triple-peptide neuroprotective blend. Pinealon is a bioregulatory peptide that acts on the pineal gland to restore natural melatonin production and circadian rhythm. PE-22-28 is a neurotrophic peptide that increases brain-derived neurotrophic factor (BDNF) for cognitive function and neural growth. Selank is a synthetic analog of the immune peptide tuftsin that modulates GABA and serotonin to reduce anxiety without sedation.
The most commonly reported side effects are mild: injection site reactions (redness, slight soreness), vivid dreams during the first week as sleep architecture normalizes, and occasional mild headache. All three peptides have been studied independently with favorable safety profiles. No sedation, no dependence, and no cognitive impairment have been reported.
This combination is not recommended if you are pregnant or breastfeeding, have active cancer, have uncontrolled thyroid conditions, or are under 18. Patients taking MAO inhibitors or SSRIs should discuss potential interactions with their provider. Always disclose your full medical history during screening.
Most patients notice improved sleep quality within 1-2 weeks. Cognitive clarity and focus improvements typically appear by weeks 2-4 as BDNF levels rise. Anxiety reduction from Selank often begins within the first week. Full compounding benefits across all three pathways are generally experienced between weeks 4-8.
PeRx ships Pinealon/PE-22-28/Selank fully reconstituted and ready to use. Store refrigerated at 36-46°F (2-8°C). Do not freeze. Keep the vial upright and away from direct light.
None of the three peptides in this blend are FDA-approved for any specific condition. The combination is available as a compounded medication prescribed by licensed providers and prepared at FDA-registered 503A pharmacies. All three compounds have been studied in published research.
Nope! The entire process is done online. Complete a health screening, a licensed provider reviews your profile remotely, and your medication ships directly to your door via FedEx Overnight.
Every order includes a provider evaluation and prescription, pharmacy-grade Pinealon/PE-22-28/Selank from an FDA-registered 503A pharmacy, insulin syringes, alcohol swabs, a step-by-step injection guide, and FedEx Overnight shipping.
Yes. This blend pairs well with DSIP (for enhanced deep sleep support), Epitalon (for telomere protection and longevity), and NAD+ (for cellular energy and DNA repair). Your provider can advise on combinations based on your health goals.
Selank is not currently on the WADA prohibited list, and Pinealon and PE-22-28 are newer peptides that may not yet be specifically listed. However, athletes subject to anti-doping testing should consult with their provider and governing body before use, as prohibited substance lists are updated regularly.
You may also be interested in
Semax/Selank
Anxiety + Focus
Anxiolytic and cognitive support from Semax and Selank
DSIP
Deep Sleep Peptide
Delta-wave sleep induction for restorative rest
Epitalon
The Longevity Peptide
Telomerase activation for cellular longevity and DNA protection
NAD+
Cellular Energy
Supports DNA repair, mitochondrial function, and cellular energy
Your guide to health and wellness starts here.
Browse our most popular articles below.
Pinealon/PE-22-28/Selank Injection
Supporting Research
- Advances in Gerontology, 2011: Pinealon & Circadian Gene Regulation
- Nature Reviews Neuroscience, 2013: BDNF & Cognitive Function
- Regulatory Peptides, 2014: Selank: Anxiolytic & Nootropic Properties
Only available if prescribed after an online consultation with a licensed healthcare provider. Benefits outlined are based on published third-party studies. Individual results may vary.
The FDA does not review or approve any compounded medications for safety or effectiveness. Compounded medications are prepared by state-licensed 503A pharmacies based on a valid prescription. If you notice any side effects, contact your healthcare provider immediately.
None of the peptides in this blend are FDA-approved for any specific condition. All are available as compounded medications through licensed providers.
Pinealon/PE-22-28/Selank
$299/mo