DSIP Dosage Chart: Units, Timing, Cycle Length

The DSIP Dosage Chart

Nearly every DSIP Explore PeRxDSIPDeep Sleep PeptideView peptide dosage chart on the internet was built for a different product: a dry powder the buyer dissolves at home, where the final concentration depends on how much liquid went into the vial that day. Those charts need three inputs and a calculator. This one needs none of that. PeRx DSIP ships fully reconstituted and ready to use at a fixed 1 mg per mL, so the concentration never varies from vial to vial and the conversion is the same every night.

Here is the arithmetic once, so the table below makes sense. A U-100 insulin syringe holds 100 units per mL, which makes each unit 0.01 mL. At 1 mg per mL, a full mL carries 1,000 mcg, so each unit carries 10 mcg. Units equals micrograms divided by 10. DSIP happens to have the friendliest math in the catalog, because every common dose lands on a round number of units.

DSIP

Every number on this page assumes the standardized PeRx vial: 5 mL at 1 mg/mL, 5 mg of DSIP total, shipped cold overnight with insulin syringes in the box. There is no powder and nothing to mix.

DSIP is prescribed by a licensed provider after a health screening and compounded at a US-based 503A pharmacy with testing on every batch. A vial is $229 and covers a month on the Monday through Friday schedule.

The ready-to-use 1 mg/mL vial the chart above assumes.

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What PeRx Prescribes for DSIP

That box is the whole label, and this page stays on the numbers inside it. Site selection is a separate question with a short answer, abdomen or thigh, and a longer one about rotation and low-light technique covered in where to inject DSIP Read nextWhere to Inject DSIP: Sites and Bedtime TimingDSIP is a subcutaneous injection, and the honest answer is that the clock matters more than the map. The dose goes in at bedtime, Monday through Friday. Here is the site rundown, the technique that fits a nighttime routine, and the safety rules that actually change how you take it.Read article . If you have never given yourself a subcutaneous injection of anything, how to inject peptides Read nextHow to Inject Peptides: Subcutaneous GuideA clear, practical walkthrough of subcutaneous peptide injections, from supply setup to sharps disposal. Written for patients new to self-injection with ready-to-use PeRx vials.Read article walks through the mechanics from the first alcohol swab. And for what DSIP actually is, a nonapeptide pulled from the cerebral blood of sleeping rabbits in the 1970s with one of the strangest research histories in the field, start with the DSIP pillar guide Read nextDSIP Peptide: Delta Sleep-Inducing Peptide GuideDiscovered in 1974. Found in your brain, your gut, and your breast milk. Over 500 studies published. And yet: no one has ever found its gene. DSIP does not sedate you. It restores the deep, restorative sleep architecture your body has been losing since childhood. Here is everything science knows about the delta sleep-inducing peptide, everything it does not, and why that mystery might be the most interesting part.Read article .

What the DSIP Trials Actually Dosed

A DSIP dosage page owes you some honesty before it hands you a number. DSIP was characterized in 1977 by Schoenenberger and Monnier in Basel, and the bulk of its human literature dates from the decade that followed, small European and Soviet-era studies with methods that vary from paper to paper. That literature is where every modern protocol ultimately borrows its credibility, so it is worth knowing what it actually says about dose.

Schoenenberger GA, Monnier M. "Characterization of a delta-electroencephalogram (-sleep)-inducing peptide." Proceedings of the National Academy of Sciences. 1977;74(3):1282-1286. View study

The most encouraging human data comes from Schneider-Helmert, who gave 18 chronic insomniacs six intravenous doses of 30 nmol per kilogram across a single week in a sleep laboratory. Sleep normalized in the middle-aged group by the end of the dosing week and in the older group by the end of a follow-up week, and the whole sample showed normal sleep patterns when the study closed. A small study without the machinery of a modern trial, but a real polysomnography result.

Schneider-Helmert D. "Efficacy of DSIP to normalize sleep in middle-aged and elderly chronic insomniacs." European Neurology. 1986;25(6):448-453. View study

The most rigorous study is less flattering. Bes and colleagues ran a double-blind, placebo-controlled trial in 16 chronic insomniacs at 25 nmol per kilogram intravenously and found higher sleep efficiency and shorter sleep latency with DSIP, then noted in their own discussion that the significant effects were weak and concluded short-term DSIP was unlikely to be of major therapeutic benefit. A 2006 review by Kovalzon and Strekalova went further, pointing out that no gene, precursor, or receptor for DSIP has ever been identified and calling the sleep-factor hypothesis poorly documented.

Bes F, Hofman W, Schuur J, Van Boxtel C. "Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study." Neuropsychobiology. 1992;26(4):193-197. View study

Kovalzon VM, Strekalova TV. "Delta sleep-inducing peptide (DSIP): a still unresolved riddle." Journal of Neurochemistry. 2006;97(2):303-309. View study

Now notice what those trial doses were. At DSIP’s molecular weight, 25 to 30 nmol per kilogram works out to roughly 1.5 to 1.8 mg for a 70 kg adult, given intravenously. The subcutaneous doses prescribed today are about a tenth of that, by a different route, and no study has ever mapped one onto the other or established a dose-response curve at any dose. That is the honest foundation under every DSIP chart, including this one: the conversion table is exact, and the biology behind the chosen dose is not. It is also why the label, not the literature, governs what you inject.

Why DSIP Is Dosed at Bedtime

DSIP degrades fast, with a half-life around 15 minutes in vitro, and whatever it does to sleep architecture it does around the transition into sleep. The protocol is built for that window: the injection goes in right before you lie down, so the peptide’s brief active period overlaps the moment your brain is deciding whether to descend into slow-wave sleep. Taking it at lunch is not a small scheduling change. It is a different protocol, and not the prescribed one.

Unlike the growth hormone peptides, DSIP carries no fasting rule; dinner does not blunt it as far as anyone has shown. The cautions that do matter are about what DSIP is: a compound taken for sleep. The PeRx instructions say not to drive or operate machinery until you know how it affects you, and to be careful stacking it with alcohol or sedating medications the provider has not signed off on. Where the sleep peptides sit relative to each other, and why depth and timing are different problems, is mapped in the best peptides for sleep Read nextBest Peptides for Sleep: A Research-Backed GuideYou already know sleep matters. You have tried melatonin, magnesium, and sleep hygiene. You still wake up at 3 AM. Peptide therapy targets the biological systems that regulate sleep architecture, not just the timing of when you fall asleep. Here are the best-studied peptide options for deep sleep, nighttime stress, and overnight recovery, with honest notes on how strong the evidence actually is for each.Read article .

The 100 to 250 mcg DSIP Range

Search for DSIP dosing and the range you will meet everywhere is 100 to 250 mcg before bed. That range is clinical convention, the band most prescribers and compounding protocols have settled into, and it is worth being clear that convention is what it is: the trials above did not test it, and there is no published curve showing 250 mcg outperforms 100 mcg. At the PeRx concentration the endpoints are simply 10 and 25 units on the syringe, and the PeRx prescription sits at 200 mcg, inside the band and on a round 20-unit draw that is easy to read at eleven at night.

The absence of a dose-response curve cuts one way in practice: more is not better, it is just more. If the effect you notice at 200 mcg is nothing, doubling the draw has no evidence behind it and grogginess against it. The PeRx instructions are blunt on that last point: waking up groggy means the dose was too high for you, and the printed guidance is to halve the next one. Raise anything beyond that with your provider at the renewal check-in, and if a dose change is warranted it will arrive as a new instruction on the label, which always outranks a table on a blog.

DSIP Cycle Length: How Long to Run It

Tolerance and dependence have not been documented in the DSIP literature, and the practical consequence shows up in how it is scheduled. DSIP is one of the few peptides that can be run continuously without a mandated off period; typical courses run three to six months with a re-evaluation at each renewal, and some patients use it only on nights when sleep has been poor, which is functional rather than scheduled cycling. Both patterns and the reasoning behind them are laid out in the peptide cycling guide Read nextPeptide Cycling Chart: When to Pause Each ClassPeptide therapy is rarely meant to run forever. Some peptides need scheduled breaks to keep working. Others can be used continuously. The right cycle depends on the peptide class, your goals, and what is happening at the receptor level. Here is the practical guide to cycling, peptide by peptide.Read article .

The vial math is tidy either way. Twenty units, Monday through Friday, empties a 5 mL vial in 25 doses, five weeks of school-night sleep on a one-vial-per-month prescription at $229. Two off nights a week also give you a built-in read on progress: if Saturday sleep without an injection starts resembling Wednesday sleep with one, that is worth mentioning at the renewal. And whatever the syringe is doing, the boring fundamentals still carry most of the load. DSIP layers onto consistent sleep and wake times, a dark cool room, and restrained caffeine; it does not replace them, and it is not a sedative, a distinction unpacked in DSIP vs melatonin Read nextDSIP vs Melatonin: Different Sleep, Different FixMelatonin tells your body it is dark. DSIP restructures how deep you sleep. One regulates timing, the other regulates quality. They target completely different sleep systems, which is why most people who take melatonin still wake up unrefreshed. Here is the comparison.Read article .

DSIP and the July 2026 FDA Vote

One regulatory note belongs on a 2026 dosing page. On July 24, 2026, the FDA’s Pharmacy Compounding Advisory Committee finished a two-day review of seven peptides proposed for the 503A bulks list and recommended six of them. The one it declined was Emideltide, the compounding name for DSIP, in a narrow 6-7 vote. That is a declined recommendation, not a ban and not a scheduling action. DSIP came off the FDA’s restricted Category 2 list in April 2026 and sits in the same gray zone today as it did the week before the meeting: prescribed by a licensed provider, compounded by a licensed 503A pharmacy. Advisory votes feed a formal rulemaking process that takes a year or more, and nothing about the vote changes the dose, the schedule, or the label. The full tally and what it does and does not mean is in the FDA panel article Read nextFDA Panel Backs 6 of 7 Peptides, Rejects DSIPThe FDA's Pharmacy Compounding Advisory Committee finished its two-day meeting on July 24, 2026. By the end, it had voted to recommend six of the seven peptides on the agenda for the 503A compounding list, including BPC-157, TB-500, MOTS-C, Semax, and Epitalon, and against just one, Emideltide (DSIP). Every vote went against the FDA's own scientists. Here is the full tally, what it changes, and what it does not.Read article , and the longer regulatory history lives in is DSIP FDA approved Read nextIs DSIP FDA Approved? 500 Studies, No US TrialNo. DSIP has never entered clinical trials, never been submitted for FDA approval, and remains one of the strangest molecules in neuroscience. Over 500 studies published. No gene ever found. No receptor identified. No pharmaceutical sponsor. And yet it is one of the most effective sleep peptides in clinical use. Here is why the regulatory gap exists.Read article .

DSIP Dosage: Common Questions