MOTS-C Injection
The Mitochondrial Exercise Mimetic
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Get StartedMOTS-C is a mitochondrial-derived peptide your body naturally produces during exercise. It activates the same metabolic pathways as physical activity, improving how your cells process glucose, burn fat, and produce energy. Production declines with age, which is part of why metabolism slows over time.
MOTS-C may support improved insulin sensitivity, enhanced mitochondrial function, better exercise capacity, healthier body composition, and metabolic resilience. In animal studies, old mice treated with MOTS-C doubled their treadmill running capacity.
MOTS-C is administered as a simple subcutaneous injection. Typical dosing includes injections on a provider-determined schedule. PeRx ships it fully reconstituted and ready to use. Insulin syringes and a step-by-step guide are included.
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The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
*The FDA does not review or approve any compounded medications for safety or effectiveness. Off-label use must be prescribed and supervised by a licensed provider.
Your metabolism slowed down. MOTS-C wakes it back up.
Your body produces MOTS-C naturally during exercise. It tells your cells to burn fuel, build mitochondria, and stay metabolically flexible. But production drops as you age. That's part of why the same workout at 45 doesn't deliver what it did at 25.
In a 2021 Nature Communications study, old mice treated with MOTS-C doubled their treadmill running capacity. The researchers also found that exercise increased MOTS-C levels up to 11.9x in human skeletal muscle. Supplementing restores what your body used to make on its own so your training, nutrition, and effort actually produce the results they should.
Why do people explore MOTS-C therapy?
May enhance exercise capacity and endurance by activating the same metabolic pathways as physical training.
May improve body composition by shifting your metabolism from fat storage to fat burning at the cellular level.
May support insulin sensitivity and glucose regulation, helping your body use fuel more efficiently.
May boost mitochondrial function, giving your cells more energy factories and higher metabolic capacity.
May support healthy aging by maintaining metabolic flexibility as natural MOTS-C production declines with age.
Published in Nature Communications and Cell Metabolism. The science behind the exercise mimetic. Read the guide →
What the research shows about MOTS-C
Lab tested medications
for quality & potency
Our medication is compounded at FDA-registered, state-licensed 503A pharmacies and delivered right to your door when you need it.
Lab tested for quality & potency
Our pharmacies perform third-party testing through FDA and DEA registered labs to run quality control checks for every compounded lot. They test four key characteristics associated with quality and safety.
Potency Test
PASSEDPerformed on every batch to confirm the active ingredient is present at the labeled concentration. Your vial contains exactly what it should.
Sterility Test
PASSEDTests for the presence of bacteria, fungi, and other microorganisms. Every batch is tested and must meet the requirements of USP 797.1.
Endotoxin Test
PASSEDScreens for bacterial endotoxins that can cause fever or adverse reactions. Every batch is tested and must not exceed the threshold limits defined in USP 85.
pH Test
PASSEDAssesses the acid/base balance to ensure minimal irritation upon injection and confirm the solution is within the correct range for subcutaneous administration.
Quality you can trust
Get started in 3 simple steps
No appointments. No waiting rooms. Everything happens online.
Complete your health screening online
Step
1
Answer a quick clinical questionnaire 100% online. A licensed provider reviews your profile to determine if a personalized treatment plan is right for you.
Get your medication delivered to your door
Step
2
Once approved, your prescription ships directly to you via FedEx Overnight in cold-chain packaging. Fully reconstituted and ready to use from day one.
Ongoing care and provider support
Step
3
Your prescribing provider is available anytime for questions. Plus, regular check-ins help track your progress and adjust your protocol as needed.
MOTS-C vs. AOD-9604
Two metabolic peptides. Different approaches to fat loss and metabolism.
MOTS-C
Exercise mimetic
| MOTS-C | AOD-9604 | |
|---|---|---|
| Best For | Metabolic optimization, exercise capacity, aging athletes | Targeted fat loss, weight management |
| How It Works | Activates AMPK pathways (mimics exercise at cellular level) | Stimulates lipolysis, inhibits fat storage (GH fragment) |
| Scope | Systemic: metabolism, mitochondria, insulin, endurance | Focused: fat breakdown and lipid metabolism |
| Ideal If You Have | Metabolic slowdown, declining exercise benefits, longevity goals | Stubborn fat deposits, want targeted fat reduction |
| Can Combine? | Yes — pairs well with AOD-9604, NAD+ | Yes — pairs well with MOTS-C |
Want both? AOD 9604/MOTS-C Combo
Attack fat from two angles: AOD-9604 drives lipolysis while MOTS-C improves how your cells process fuel. Comprehensive metabolic optimization in a single vial.
View AOD 9604/MOTS-C Combo
AOD-9604
Fat loss fragment
What to Expect: Your MOTS-C Timeline
Every body is different, but here's the typical progression.
What you may notice:
Subtle improvements in energy and workout recovery. You may feel more alert in the morning. Blood sugar may feel more stable between meals.
What's happening:
AMPK pathways are activating. Your cells are beginning to shift toward more efficient glucose metabolism and fat oxidation.
What you may notice:
Workouts feel more productive. Endurance improves. Recovery between sessions shortens. You may notice less afternoon energy dips.
What's happening:
New mitochondria are forming in muscle tissue. Your cells have more energy factories online, improving both capacity and efficiency.
What you may notice:
Clothes fit differently. Midsection tightens. Muscle tone improves. Training performance continues to climb.
What's happening:
Metabolic flexibility is improving. Your body is better at switching between fuel sources. Fat oxidation increases while lean mass is preserved.
What you may notice:
Consistent energy, improved body composition, better metabolic markers. The changes feel stable rather than temporary.
What's happening:
Metabolic improvements are well-established. Insulin sensitivity, mitochondrial density, and fat metabolism are operating at a higher baseline.
More from our patients
Real experiences. Individual results may vary.
My workouts are producing results again
“At 42, my training stopped delivering. Same effort, zero progress. Two months on MOTS-C and my endurance is back, recovery is faster, and the midsection fat is finally moving.”
Jason R.
MOTS-C
Energy I haven’t felt in years
“The afternoon crashes are gone. I have steady energy from morning to evening. My fasting glucose numbers have improved too. This peptide is doing something real at the cellular level.”
Karen D.
MOTS-C
Better than any supplement I’ve tried
“I track everything. Heart rate variability, glucose, body comp. After 6 weeks on MOTS-C, every marker is trending in the right direction. The data speaks for itself.”
Mike T.
MOTS-C
The exercise mimetic is real
“I was skeptical about the "exercise in a bottle" claims. But my VO2 max has improved and I’m recovering faster between interval sessions. Not a replacement for training, but a serious amplifier.”
Sandra L.
MOTS-C
Metabolism finally woke up
“Post-50, my metabolism just stopped. Diet and exercise barely moved the needle. MOTS-C was the missing piece. Body comp is changing for the first time in five years.”
David H.
MOTS-C
Individual results may vary. Testimonials reflect personal experiences and do not guarantee outcomes.
Learn more about
MOTS-C Injection
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a mitochondrial-derived peptide that your body naturally produces during exercise. It activates AMPK signaling pathways to regulate glucose metabolism, fatty acid oxidation, and mitochondrial function. Production naturally declines with age.
The most commonly reported side effects are mild: injection site irritation (redness, slight soreness) that usually resolves in minutes, and brief GI discomfort in the first week. MOTS-C is a newer peptide with strong preclinical data but limited long-term human studies. Research is ongoing.
MOTS-C is not recommended if you are pregnant or breastfeeding, have active cancer, or have autoimmune conditions without provider clearance. Diabetic patients should discuss with their provider as MOTS-C may affect blood glucose levels. Always disclose your full medical history during screening.
Most patients notice subtle energy improvements within 1-2 weeks. Exercise response and recovery typically improve by weeks 2-4. Measurable body composition changes usually appear by weeks 4-8, with sustained optimization at 8-12+ weeks.
PeRx ships MOTS-C fully reconstituted and ready to use. Store refrigerated at 36-46°F (2-8°C). Do not freeze. Keep the vial upright and away from direct light.
MOTS-C is not FDA-approved for any specific condition. It is available as a compounded medication prescribed by licensed providers and prepared at FDA-registered 503A pharmacies. Research is ongoing with strong preclinical data published in journals like Nature Communications and Cell Metabolism.
No. The entire process is done online. Complete a health screening, a licensed provider reviews your profile remotely, and your medication ships directly to your door via FedEx Overnight.
Every order includes a provider evaluation and prescription, pharmacy-grade MOTS-C from an FDA-registered 503A pharmacy, insulin syringes, alcohol swabs, a step-by-step injection guide, and FedEx Overnight shipping.
Yes. MOTS-C pairs well with AOD-9604 (dual-angle metabolic optimization, available as a combo vial), NAD+ (cellular energy synergy), and CJC-1295/Ipamorelin (metabolic + GH support). Your provider can advise on combinations.
No. MOTS-C activates some of the same metabolic pathways as exercise but it is not a substitute for physical activity. Think of it as a way to restore the metabolic responsiveness you had when you were younger, so your workouts and nutrition actually produce the results they should.
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AOD 9604/MOTS-C
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The Original GH Peptide
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Your guide to health and wellness starts here.
Browse our most popular articles below.
MOTS-C Injection
Supporting Research
- Nature Communications, 2021: Exercise-Induced Regulator of Physical Decline
- Cell Metabolism, 2015: The Discovery Paper: Metabolic Regulation
- Aging, 2020: MOTS-c Expression and Aging in Muscle
Only available if prescribed after an online consultation with a licensed healthcare provider. Benefits outlined are based on published third-party studies. Individual results may vary.
The FDA does not review or approve any compounded medications for safety or effectiveness. Compounded medications are prepared by state-licensed 503A pharmacies based on a valid prescription. If you notice any side effects, contact your healthcare provider immediately.
MOTS-C is a research peptide with strong preclinical data but limited long-term human clinical trials. Published studies appear in journals including Nature Communications and Cell Metabolism.
MOTS-C
$229/mo