Refuels every cell's power plant
Your cells turn food into energy using NAD+ — when it drops, output drops, and you feel it as fatigue, fog, and slow recovery. Restoring it re-enables the process, system-wide.
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NAD+ Injection
The Cellular Energy Coenzyme
New here? Use code WELCOME10 at checkout for 10% off your first order: $206/mo on a 1-month supply.
Anti-Aging
Replenishes a vital coenzyme for DNA repair, energy production, and longevity.
$229 / month
Starting at $175/mo with 3-month supply + WELCOME10
- Restores cellular energy production
- Supports DNA repair and genomic stability
- Enhances mitochondrial function
- Improves cognitive clarity and focus
- Activates sirtuin longevity pathways
Dosage100 mg/mL, 10 mL vial
AdministrationSubcutaneous injection
Compounded in the U.S.A.
About
What is NAD+?
NAD+ — nicotinamide adenine dinucleotide — is a coenzyme in every cell you have, and it is not optional: it is required for energy metabolism, for DNA repair, and for the sirtuin and PARP enzymes that regulate aging-related pathways. Levels fall roughly 50% by middle age, which is part of why fatigue, brain fog, and slower recovery creep in.
Replenishing NAD+ re-fuels the machinery your body already has. Clinical work on NAD+ precursors shows blood NAD+ can roughly double within days and rise 2.6–3.1× over a few weeks, with preclinical data tying restoration to better mitochondrial function, cardiovascular markers, muscle endurance, and cognition. PeRx delivers it as a subcutaneous injection, which bypasses the gut entirely for higher bioavailability than oral NMN or NR.
PeRx ships NAD+ fully reconstituted from an FDA-registered 503A pharmacy. No mixing — insulin syringes and a step-by-step guide arrive in the box. It is a subcutaneous injection on a provider-determined schedule.
Why do people explore NAD+ therapy?
Restores the cellular energy production that declines with NAD+ loss, so mornings stop feeling like a climb.
Fuels mitochondrial function in muscle cells, which sharpens recovery and lifts capacity on training days.
Supports brain cell energy metabolism and neuronal repair, the quiet foundation for clear thinking and focus.
Activates sirtuin longevity pathways and DNA repair across roughly 10,000 damage events your cells handle daily.
Restores NAD+ levels across every tissue type, the coenzyme immune cells and cardiovascular tissue rely on.
Why people explore NAD+
A clearer path forward.
Keeps your DNA repair crew running
Your body fixes on the order of 10,000 DNA damage events a day, and the enzymes doing it (PARPs, sirtuins) burn NAD+ as fuel. Low NAD+ means slower repair; replenishing it speeds the crew back up.
NAD+ is a cofactor for 500+ enzymatic reactions across every cell.
Works everywhere, not one system
NAD+ decline hits brain, muscle, liver, skin, and cardiovascular tissue alike. Restoring it doesn't target one problem — it turns the repair machinery back on wherever it is needed.
What it helps with
Designed for these concerns.
- Restores cellular energy production
- Supports DNA repair and genomic stability
- Enhances mitochondrial function
- Improves cognitive clarity and focus
- Activates sirtuin longevity pathways
- May reduce age-related fatigue
- Supports immune cell function
Ideal for
Adults experiencing age-related energy decline · Those focused on longevity and cellular health · Individuals seeking cognitive enhancement · Anyone interested in anti-aging optimization
The science
How NAD+ works.
NAD+ fuels sirtuins (SIRT1-7) and PARPs — enzymes responsible for DNA repair, gene expression regulation, and mitochondrial biogenesis. Replenishing NAD+ restores cellular energy production, activates longevity pathways, and supports the body's natural repair mechanisms.
01
Signal
NAD+ is given as a subcutaneous injection on a provider-determined schedule — the SubQ route bypasses the gut for higher bioavailability than oral NMN or NR.
02
Cellular response
NAD+ fuels sirtuins (SIRT1–7) and PARPs — the enzymes responsible for DNA repair, gene-expression regulation, and mitochondrial biogenesis. Replenishing it restores cellular energy production, activates longevity pathways, and supports the body's natural repair mechanisms.
03
Outcome
Over the following weeks most people notice morning energy and focus first (weeks 1–2), then sharper cognition and faster workout recovery (weeks 2–4), then steadier all-day energy and more restorative sleep as restoration reaches more tissues (weeks 4–8).
Subcutaneous injectionCompounded in the U.S.A. at a 503A pharmacyProvider-prescribed
What the research shows
Backed by published science.
~50%
Drop in NAD+ levels by middle age
2–3×
Increase in blood NAD+ after supplementation (clinical data)
500+
Enzymatic reactions that require NAD+
~10,000
DNA damage events your cells repair daily (NAD+-fueled)
- Studies demonstrate age-related NAD+ decline is reversible with supplementation
- Research shows sirtuin activation and improved mitochondrial function
- Trials on cognitive improvement and neuroprotection
- Emerging data on healthspan and longevity extension
Lab tested medications
for quality & potency
Our medication is delivered from a state-licensed pharmacy in our network, right to your door when you need it.
Third-party quality control testing
Compounded in U.S. pharmacies
Lab tested for quality & potency
Our pharmacies perform third-party testing through FDA and DEA registered labs to run quality control checks for every compounded lot. They test four key characteristics associated with quality and safety.
Potency Test
PassedPerformed on every batch to confirm the active ingredient is present at the labeled concentration. Your vial contains exactly what it should.
Sterility Test
PassedTests for the presence of bacteria, fungi, and other microorganisms. Every batch is tested and must meet the requirements of USP 797.1.
Endotoxin Test
PassedScreens for bacterial endotoxins that can cause fever or adverse reactions. Every batch is tested and must not exceed the threshold limits defined in USP 85.
pH Test
PassedAssesses the acid/base balance to ensure minimal irritation upon injection and confirm the solution is within the correct range for subcutaneous administration.
What to expect
Your NAD+ timeline.
- 01
Week 1–2
Energy baseline
What you may notice: Subtle improvement in morning energy. The fog starts to lift. Sleep quality may improve. Some people notice better focus during the workday.
What’s happening: NAD+ levels are rising in your cells. Mitochondria are starting to produce energy more efficiently.
- 02
Week 2–4
Cognitive clarity
What you may notice: Sharper thinking. Easier to stay focused for long stretches. Physical recovery from workouts improves. The after-lunch slump starts to fade.
What’s happening: Sirtuin and PARP enzymes are ramping up with more fuel available. DNA repair and gene expression are normalizing.
- 03
Week 4–8
Systemic improvement
What you may notice: Consistent energy throughout the day. Exercise performance improves. Skin may start to look healthier. Sleep becomes more restorative.
What’s happening: NAD+ restoration is reaching tissues throughout the body. Mitochondrial biogenesis is increasing.
- 04
Week 8–12+
Sustained optimization
What you may notice: Full-body improvements become the new normal. You feel like you did years ago — recovery, cognition, and energy all elevated.
What’s happening: Cellular repair machinery is running at restored capacity. Most people maintain their protocol or adjust with their provider.
Comparison
NAD+ vs. Oral NMN / NR supplements
Same goal — raising NAD+ — but the delivery makes the difference.
| NAD+ | Oral NMN / NR supplements | |
|---|---|---|
| Bioavailability | High — the SubQ injection bypasses digestion entirely | Low — significant losses in the stomach, gut, and liver |
| How it works | Subcutaneous injection, straight into the bloodstream | A precursor that must survive stomach acid and liver processing before your cells see it |
| Convenience | Self-inject at home, takes minutes | Daily pill — easy, but lower absorption |
| Grade | Pharmaceutical-grade, compounded by a licensed pharmacy | Supplement-grade, over-the-counter |
| Can combine? | Yes — pairs well with Epitalon, MOTS-c, Glutathione | Yes, but absorption limits the stacking benefit |
What’s included
Everything you need to start safely.
From the moment you finish your assessment to your first dose, every step is handled by licensed providers and U.S. pharmacies.
New to self-injection? See the step-by-step guide- Provider evaluation and prescription
- Pharmacy-grade medication from an FDA-registered 503A pharmacy
- Insulin syringes and alcohol swabs
- Step-by-step administration guide
- FedEx Overnight cold-chain shipping
- On-demand messaging with your provider
FAQ
Common questions about NAD+.
Patient reviews
What patients are saying.
No reviews yet. Be the first verified patient to share your experience.
This is not medical advice. Every patient's experience differs and not everyone qualifies for peptide therapy. All reviews are from verified PeRx patients and are published as submitted. Peptide therapy requires a valid prescription from a licensed provider.
Your safety, first
Important safety information.
- Generally well tolerated
- May cause mild injection site irritation
- Should be administered under licensed provider supervision
- Monitor in patients with active malignancies
All prescriptions are issued by a licensed US provider after reviewing your intake.
Side effects, contraindications, and what to discuss with your provider before starting.
Read safety informationSupporting research
Selected studies.
A selection of peer-reviewed work on NAD+. Browse the full literature on PubMed and Google Scholar for ongoing research.
NAD+ decline as a driver of cellular aging
Imai S & Guarente L. Trends Cell Biol. 2014;24(8):464–471.NAD+ boosting: the in vivo evidence
Rajman L et al. Cell Metab. 2018;27(3):529–547.NAD+ in regenerative medicine (review)
Conlon N. Plast Reconstr Surg. 2022.
The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The FDA does not review or approve compounded medications for safety or effectiveness. Off-label use must be prescribed and supervised by a licensed provider.
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Last updated April 2026
Medical disclaimer
The information provided on this page is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. Peptide therapy requires a valid prescription from a licensed healthcare provider. Individual results may vary. No specific outcomes are guaranteed.
The peptides on this site are not FDA-approved. They are compounded by licensed pharmacies under provider supervision. Certain peptides are prohibited by WADA and major sports organizations. Statements on this page have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
Ready to start with NAD+?
Take our 2-minute assessment. A licensed US provider reviews and, if appropriate, prescribes a protocol shipped to your door.
$229 / month
Starting at $175/mo with 3-month supply + WELCOME10