Two pathways, one shot
Most GH peptides work through a single receptor pathway. This one works through two — GHRH (tesamorelin) and ghrelin (ipamorelin) — so you get a bigger, cleaner GH output and a broader effect from one daily injection.
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Tesamorelin/Ipamorelin
Advanced Metabolic & GH Combo
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Growth Hormone
Dual-pathway GH combo targeting visceral fat and lean body composition.
$299 / month
Starting at $229/mo with 3-month supply + WELCOME10
- Targeted visceral fat reduction
- Enhanced lean muscle mass
- Improved metabolic function
- Better sleep quality
- Increased energy and recovery
Dosage2mg/mL (Tesamorelin) + 1mg/mL (Ipamorelin), 5mL vial
AdministrationSubcutaneous injection
Compounded in the U.S.A.
About
What is Tesamorelin/Ipamorelin?
Tesamorelin/Ipamorelin puts two growth-hormone peptides in a single vial, working through two different pathways. Tesamorelin is a GHRH analog — the only peptide in its class with FDA approval (for HIV-associated lipodystrophy) — and it drives fat breakdown specifically in visceral adipose tissue. Ipamorelin is a selective GH secretagogue that triggers clean GH pulses without raising cortisol, prolactin, or appetite.
Run together, the two amplify each other: tesamorelin handles the targeted fat-burning while ipamorelin adds clean GH output to support lean tissue and recovery — so fat loss and muscle preservation move in the same direction instead of fighting each other. The result is a more aggressive body-composition protocol than either GHRH analog alone.
PeRx ships Tesamorelin/Ipamorelin fully reconstituted from an FDA-registered 503A pharmacy. No mixing — insulin syringes and a step-by-step guide arrive in the box. It is a single daily subcutaneous injection on a provider-determined schedule.
Why do people explore Tesamorelin/Ipamorelin therapy?
Targets the visceral fat that diet and exercise alone cannot reach. FDA-approved, clinically proven.
Lean muscle grows while fat drops. Two peptides, two pathways — both goals move at once, not in conflict.
Growth hormone peaks during deep sleep. This combination supports that natural rhythm for better overnight recovery.
Daily energy climbs and workout recovery shortens as metabolic function and lipid profiles normalize.
Insulin sensitivity improves and lipid levels follow. Metabolic health addressed from every angle at once.
Why people explore Tesamorelin/Ipamorelin
A clearer path forward.
Targeted visceral fat loss
Tesamorelin is the only peptide FDA-approved for reducing visceral fat — the deep belly fat tied to metabolic disease. In trials that meant about a 15% reduction over 26 weeks, while sparing subcutaneous fat and lean muscle.
~15% visceral fat reduction over 26 weeks in Phase III trials.
Fat down, muscle held
Ipamorelin's clean GH release supports protein synthesis and recovery, so you keep (or build) lean tone while the fat drops — and triglycerides and lipid markers tend to improve alongside the body-composition change.
What it helps with
Designed for these concerns.
- Targeted visceral fat reduction
- Enhanced lean muscle mass
- Improved metabolic function
- Better sleep quality
- Increased energy and recovery
- Clean GH release profile
- Supports healthy lipid levels
Ideal for
Adults seeking aggressive body composition changes · Those with stubborn visceral fat · Individuals wanting dual-pathway GH optimization · Those looking for metabolic support with muscle preservation
The science
How Tesamorelin/Ipamorelin works.
Tesamorelin activates GHRH receptors for sustained GH release and targeted lipolysis, while Ipamorelin selectively triggers ghrelin-pathway GH secretion. Together they amplify fat-burning and muscle-sparing effects without cortisol or prolactin spikes.
01
Signal
Tesamorelin/Ipamorelin is given as a single daily subcutaneous injection on a provider-determined schedule.
02
Cellular response
Tesamorelin activates GHRH receptors for sustained GH release and targeted lipolysis in visceral fat, while Ipamorelin selectively triggers ghrelin-pathway GH secretion. Together they amplify fat-burning and muscle-sparing effects without cortisol or prolactin spikes.
03
Outcome
Over the following weeks most people notice better sleep and a small energy lift first (weeks 1–2), then a looser waistband and faster recovery (weeks 2–4), then measurable belly-fat reduction and visible body-composition change (weeks 4–8), with the strongest results from week 8 onward.
Subcutaneous injectionCompounded in the U.S.A. at a 503A pharmacyProvider-prescribed
What the research shows
Backed by published science.
15%
Visceral fat reduction over 26 weeks (Tesamorelin, Phase III)
2 pathways
GHRH + ghrelin — dual GH stimulation
FDA-approved
Tesamorelin component, for visceral-fat reduction
12 mo
Trunk-fat & triglyceride benefits sustained over a year (study)
- Tesamorelin FDA-approved for visceral fat reduction
- Ipamorelin well-studied for selective GH release
- Complementary mechanisms maximize body composition benefits
- Strong safety profiles for both compounds
Lab tested medications
for quality & potency
Our medication is delivered from a state-licensed pharmacy in our network, right to your door when you need it.
Third-party quality control testing
Compounded in U.S. pharmacies
Lab tested for quality & potency
Our pharmacies perform third-party testing through FDA and DEA registered labs to run quality control checks for every compounded lot. They test four key characteristics associated with quality and safety.
Potency Test
PassedPerformed on every batch to confirm the active ingredient is present at the labeled concentration. Your vial contains exactly what it should.
Sterility Test
PassedTests for the presence of bacteria, fungi, and other microorganisms. Every batch is tested and must meet the requirements of USP 797.1.
Endotoxin Test
PassedScreens for bacterial endotoxins that can cause fever or adverse reactions. Every batch is tested and must not exceed the threshold limits defined in USP 85.
pH Test
PassedAssesses the acid/base balance to ensure minimal irritation upon injection and confirm the solution is within the correct range for subcutaneous administration.
What to expect
Your Tesamorelin/Ipamorelin timeline.
- 01
Week 1–2
Improved sleep & energy
What you may notice: Better sleep quality is often the first thing people notice. You may wake up more rested and feel a subtle uptick in daily energy.
What’s happening: Your pituitary is responding to the dual GH signal. Growth-hormone release is increasing during deep-sleep cycles.
- 02
Week 2–4
Early body-composition shifts
What you may notice: Clothes may start fitting differently. The waistband feels a bit looser. Recovery from workouts improves noticeably.
What’s happening: Tesamorelin is driving targeted lipolysis in visceral fat stores while Ipamorelin supports lean-tissue preservation.
- 03
Week 4–8
Visible changes
What you may notice: Measurable reduction in belly fat. Improved muscle tone. Better workout performance and faster recovery between sessions.
What’s happening: Sustained dual-pathway GH optimization is reshaping body composition. Metabolic markers like triglycerides often improve in this window.
- 04
Week 8–12+
Peak optimization
What you may notice: Significant visceral fat reduction. Body-composition change others start to notice. Higher baseline energy and better metabolic health.
What’s happening: The full effect of dual-pathway GH optimization is established — most people see their strongest results during this phase.
Comparison
Tesamorelin/Ipamorelin vs. CJC-1295/Ipamorelin
Two dual-pathway GH combos — here's which one fits.
| Tesamorelin/Ipamorelin | CJC-1295/Ipamorelin | |
|---|---|---|
| Best for | Visceral (belly) fat reduction + lean mass + sleep | Broad GH support and deep recovery |
| How it works | GHRH (tesamorelin) + ghrelin (ipamorelin) — dual mechanism with a visceral-fat focus | GHRH (CJC-1295) + ghrelin (ipamorelin) — dual mechanism, broad GH |
| Scope | Aggressive body-composition optimization | Broad GH support and anti-aging |
| Best if you have | Stubborn visceral fat and metabolic goals | A recovery focus with moderate fat-loss goals |
| Can combine? | Yes — pairs well with MOTS-c, AOD-9604 | Yes — pairs well with BPC-157, MOTS-c |
What’s included
Everything you need to start safely.
From the moment you finish your assessment to your first dose, every step is handled by licensed providers and U.S. pharmacies.
New to self-injection? See the step-by-step guide- Provider evaluation and prescription
- Pharmacy-grade medication from an FDA-registered 503A pharmacy
- Insulin syringes and alcohol swabs
- Step-by-step administration guide
- FedEx Overnight cold-chain shipping
- On-demand messaging with your provider
FAQ
Common questions about Tesamorelin/Ipamorelin.
Patient reviews
What patients are saying.
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This is not medical advice. Every patient's experience differs and not everyone qualifies for peptide therapy. All reviews are from verified PeRx patients and are published as submitted. Peptide therapy requires a valid prescription from a licensed provider.
Your safety, first
Important safety information.
- Generally well tolerated
- Possible injection site reactions
- Should not be used with active cancer
- Requires licensed provider supervision
All prescriptions are issued by a licensed US provider after reviewing your intake.
Side effects, contraindications, and what to discuss with your provider before starting.
Read safety informationSupporting research
Selected studies.
A selection of peer-reviewed work on Tesamorelin/Ipamorelin. Browse the full literature on PubMed and Google Scholar for ongoing research.
Visceral fat reduction with Tesamorelin
Falutz J et al. N Engl J Med. 2010;362(9):846–858.Ipamorelin: selective GH release
Raun K et al. Eur J Endocrinol. 1999;141(2):180–189.Tesamorelin metabolic benefits over 12 months
Stanley TL et al. J Clin Endocrinol Metab. 2012;97(3):983–991.
The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The FDA does not review or approve compounded medications for safety or effectiveness. Off-label use must be prescribed and supervised by a licensed provider.
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Last updated April 2026
Medical disclaimer
The information provided on this page is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. Peptide therapy requires a valid prescription from a licensed healthcare provider. Individual results may vary. No specific outcomes are guaranteed.
The peptides on this site are not FDA-approved. They are compounded by licensed pharmacies under provider supervision. Certain peptides are prohibited by WADA and major sports organizations. Statements on this page have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
Ready to start with Tesamorelin/Ipamorelin?
Take our 2-minute assessment. A licensed US provider reviews and, if appropriate, prescribes a protocol shipped to your door.
$299 / month
Starting at $229/mo with 3-month supply + WELCOME10