Sermorelin Dosage Chart: Units, Timing, Cost

The Sermorelin Dosage Chart

Almost every sermorelin dosage chart you will find starts with a vial of powder, a syringe of diluent, and a paragraph of division. That is the right chart for that product and the wrong chart for this one. PeRx sermorelin ships fully reconstituted and ready to use. The concentration is fixed at 3 mg per mL, so the only conversion you ever need is micrograms to syringe units at that one concentration, and it never changes from vial to vial.

The arithmetic, once. A U-100 insulin syringe has 100 units per mL, so each unit is 0.01 mL. At 3 mg per mL, one mL holds 3,000 mcg and one unit holds 30 mcg. Divide micrograms by 30 to get units. Multiply units by 30 to get micrograms.

What PeRx Prescribes

That box is the entire label. Where the needle goes is its own topic: abdomen, thigh, upper glute, or the back of the arm, rotated so you never hit the same spot twice in a row. The where to inject sermorelin guide Read nextWhere to Inject Sermorelin: Sites, TimingSermorelin is a subcutaneous injection, usually taken once at bedtime. The four standard sites all work, but the timing detail is what makes sermorelin different from a daytime peptide. Here is the practical guide patients ask for after their first vial arrives, as of July 2026.Read article covers site selection and small-volume technique, and how to take peptides Read nextHow to Take Peptides: Injection, Capsule, or StripMost prescription peptides are injected under the skin, a few are swallowed, and a small category dissolves under the tongue. This is the route-of-administration hub: why the route matters, exactly how a subcutaneous injection works, when each peptide is usually taken, what arrives in a PeRx kit, and a directory of per-peptide injection-site guides.Read article is the general primer if this is your first subcutaneous injection of any kind. For what sermorelin is and how a 29-amino-acid fragment of GHRH became an FDA-approved pediatric drug and then a compounded adult one, start with the sermorelin pillar guide Read nextSermorelin 2026: The Original Growth Hormone PeptideEvery growth hormone peptide used today traces its lineage back to this molecule. Sermorelin was once FDA-approved, then abandoned for commercial reasons. Now it's having a second act as the safest entry point into growth hormone optimization. The peptide that was too gentle for children turned out to be exactly what adults needed.Read article . This page stays on the numbers and assumes you already know sermorelin works by prompting your own pituitary to release growth hormone rather than supplying the hormone directly.

Why Bedtime and Why Fasting

Two rules on the label do most of the work, and both are physiology rather than convenience. Growth hormone is released in pulses, and in adults the largest pulse of the 24-hour cycle is coupled to the first period of slow-wave sleep. Van Cauter and Plat reviewed this in the Journal of Pediatrics in 1996: deep-sleep onset and the big nightly GH pulse arrive together, and the coupling holds even when bedtime shifts. Sermorelin has a half-life measured in minutes, so a dose injected 20 or 30 minutes before you fall asleep adds to that pulse instead of landing in a dead zone at two in the afternoon.

Van Cauter E, Plat L. "Physiology of growth hormone secretion during sleep." Journal of Pediatrics. 1996;128(5 Pt 2):S32-S37. View study

Fasting is the flip side. Ho and colleagues showed in the Journal of Clinical Investigation in 1988 that a fast amplifies GH secretion in healthy men, raising both pulse frequency and pulse amplitude. The reverse is textbook endocrinology: a rise in blood glucose after a meal suppresses GH release, which is why an oral glucose load is the standard clinical test for confirming that GH can be suppressed. Injecting a GHRH analog right after dinner asks the pituitary to respond with a brake applied. Two hours releases the brake.

Ho KY, Veldhuis JD, Johnson ML, et al. "Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man." Journal of Clinical Investigation. 1988;81(4):968-975. View study

Nightly vs Five On, Two Off

Search for a sermorelin schedule and you will find two: every night, or five nights on and two off, usually weekdays on and weekends off. Both are real. Neither has a head-to-head trial behind it. The choice comes down to how a prescriber weighs total weekly exposure, the receptor-rest argument, and whether a patient will actually keep the routine.

The receptor-rest argument: GHRH receptors on pituitary somatotrophs can become less responsive under continuous stimulation, which is one reason continuous GHRH infusions in older research produced smaller GH responses than pulsed ones. A built-in two-night gap is a low-cost hedge against that. Whether it matters at adult protocol doses has not been tested directly, so it is reasoning from physiology, not proof. Prescribers who choose nightly dosing answer that every night has a slow-wave pulse worth reinforcing and that somatostatin feedback already limits how hard the pituitary can be pushed.

The practical argument is less elegant and probably more important. Monday through Friday is easy to remember, survives a weekend where dinner runs late, and counts cleanly against a vial: 25 doses, five weeks. That is the schedule on the PeRx label. If you were prescribed something different elsewhere, the label in front of you wins over anything on this page.

Dosage for Women and for Adults Over 50

Two of the most common searches on this topic are sermorelin dosage for females and sermorelin dosage over 50. The honest answer to both is that the published literature does not define a separate dose for either group, and the PeRx prescribed protocol is the same 20 units regardless of sex or age. What differs is the starting point.

On sex: in a 1987 study of 24-hour GH profiles in healthy adults, Ho and colleagues found that premenopausal women secreted more GH over the day than men of the same age, and that the difference tracked circulating estradiol. After menopause the gap narrows. So a woman in her 30s often starts from a higher natural baseline than a man her age, and a woman in her 50s often does not. That is a statement about where you begin, not about how much to inject.

Ho KY, Evans WS, Blizzard RM, et al. "Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations." Journal of Clinical Endocrinology and Metabolism. 1987;64(1):51-58. View study

On age: the human trials of GHRH(1-29) analogs in older adults enrolled men and women together at the same doses. Khorram and colleagues gave a GHRH(1-29) analog to men and women aged 55 to 71 for 16 weeks and reported increases in GH and IGF-1 in both sexes. That study used different analogs, doses, and schedules than a modern compounded protocol, so it supports the general point that older adults respond, not any particular number.

Khorram O, Laughlin GA, Yen SS. "Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women." Journal of Clinical Endocrinology and Metabolism. 1997;82(5):1472-1479. View study

The one place age does change the plan is in what a normal result looks like. IGF-1 reference ranges are age-adjusted, and a level that is unremarkable at 35 can sit at the top of the range at 65. For an older patient the baseline lab matters more than the dose does.

The IGF-1 Baseline and Retest

Growth hormone itself is a poor thing to measure. It pulses, it clears from the blood within minutes, and a random daytime draw tells you almost nothing. Insulin-like growth factor 1 is the practical proxy: the liver makes it in response to GH, it is stable across the day, and it integrates the last few weeks of GH exposure into one number.

A baseline IGF-1 before starting does two jobs. It documents where you began, so a later change means something, and it flags the small number of people whose IGF-1 already sits at or above the top of the age-adjusted range, for whom a GH secretagogue is the wrong tool. A retest after a full cycle, about three months in, answers the only question that matters: did the number move, and is it still inside the range? Your provider reviews both results at the renewal check-in. Neither test is required to order at PeRx, but both are inexpensive and available through any standard lab.

What the Approval Visit Asks

Sermorelin is a prescription, so a licensed provider signs off before a vial ships. At PeRx that starts with a health questionnaire at checkout; your card is saved but not charged until the prescription is approved. The questions are the ones any prescriber would ask before a GH secretagogue: age and sex, current medications, any personal history of cancer, whether you are pregnant, breastfeeding, or planning a pregnancy, thyroid history, diabetes or blood sugar problems, prior use of growth hormone or GH peptides, and what you are hoping to change.

The provider approves, declines, or messages for more detail, usually within a business day. Once approved, the charge fires, the pharmacy compounds the vial, and it ships overnight in refrigerated packaging with syringes, alcohol swabs, and printed instructions. There is no monthly call and no dose titration by text. You get a protocol, a vial, and a renewal check-in when the cycle ends.

Cycle Length and What to Expect When

The PeRx label says three months on, one month off. That matches how most compounding-based protocols handle sermorelin, and it lines up with the IGF-1 retest: run a full cycle, check the lab, take the month off, then decide from a clean data point whether to restart. The month off is the receptor-rest logic from the schedules section scaled up from two nights to four weeks. One 5 mL vial at 20 units Monday through Friday is 25 doses, or five weeks, so a three-month cycle is three vials on a one-vial-per-month prescription.

As for when you notice anything: sleep tends to shift first, often within a couple of weeks, and body composition takes months. That sequence and what speeds it up or slows it down is the subject of how long sermorelin takes to work Read nextHow Long Does Sermorelin Take to Work?Sermorelin does not flip a switch. It works gradually by prompting your own pituitary to release more growth hormone, so the changes arrive in a predictable order rather than all at once. Sleep tends to shift first, then energy and recovery, then the slower body-composition and skin changes over several months. This guide lays out that arc honestly, explains what speeds it up or slows it down, and covers when to check back in with your provider.Read article , so this page will not repeat it. The dosing takeaway is that nothing about the number on the syringe changes that timeline. Injecting more does not make it arrive sooner.

Early Side Effects

Sermorelin has a longer safety record than almost any other compounded peptide because it spent 11 years as an FDA-approved product, and the side-effect list from that era is short. The Geref-era literature, summarized in a 1999 review by Prakash and Goa in BioDrugs, reports injection-site reactions as the most common complaint: pain, redness, and swelling, usually mild and gone within a day. Transient facial flushing after the injection and headache were next most frequent, and all were more common early in treatment.

Prakash A, Goa KL. "Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency." BioDrugs. 1999;12(2):139-157. View study

Adults on GH secretagogues also sometimes report mild water retention, a puffy feeling in the hands or ankles, or a dull joint ache in the first few weeks. Those are GH effects rather than sermorelin effects, they tend to settle, and their presence at a modest dose is one more reason the retest lab exists. The PeRx instructions say to contact the care team for a rash, localized hives, or a site reaction that does not resolve within a few days, and to seek emergency help for swelling of the face, throat, or tongue, difficulty breathing or swallowing, a severe headache that does not resolve, or a rapid heartbeat. The peptide side effects guide Read nextPeptide Side Effects: Normal vs. Red Flag (2026)Most peptide side effects are mild local reactions that resolve in a day. A smaller set of systemic effects depends on the pathway the peptide acts on. And a third category, the one worth paying attention to, points to a problem with the product or the patient that should pause the protocol. Here is how to tell them apart.Read article covers what is common and what is not across the catalog.

Who Is Not a Candidate

Sermorelin Cost Per Month

Sermorelin at PeRx is $229 per vial, one vial per prescription month. The price includes the provider review, the compounding, overnight refrigerated shipping, syringes, and swabs. There is no membership fee and nothing is charged until the prescription is approved. A full three-month cycle is three orders, $687 before any discount. Prices are visible on the product page Explore PeRxSermorelinThe Growth Hormone OptimizerView peptide once you have an account.

The comparison people ask about most is recombinant human growth hormone. It is a different product in a different regulatory category: an FDA-approved drug prescribed for specific diagnosed deficiencies, dispensed in branded pens, with a retail cash price set by brand and dose. Reported monthly cash costs vary widely by brand, dose, and pharmacy and commonly run from several hundred dollars into the low thousands. PeRx does not prescribe or sell it. The point is not that sermorelin is a cheaper version of the same thing. It is not the same thing. Sermorelin asks your pituitary for more of its own hormone; rhGH replaces it. For how sermorelin compares to the other secretagogues you might be weighing instead, see sermorelin vs ipamorelin vs tesamorelin Read nextSermorelin vs Ipamorelin vs Tesamorelin: Which Fits?All three raise your own growth hormone, but they pull different levers, last for different amounts of time, and suit different goals. This is a decision guide, not a spec sheet: match the peptide to what you actually want.Read article .

Common Questions